منابع مشابه
Nuclear pores and nuclear assembly.
Communication between the nucleus and cytoplasm occurs through large macromolecular structures, the nuclear pores. Quantitative scanning transmission electron microscopy has estimated the mass of a nuclear pore to be 60 million Daltons in yeast and 120 million Daltons in vertebrates. The past two years were noteworthy in that they saw: 1) the purification of both the yeast and vertebrate nuclea...
متن کاملCytoplasmic dynein is required for normal nuclear segregation in yeast.
We have identified the gene DYN1, which encodes the heavy chain of cytoplasmic dynein in the yeast Saccharomyces cerevisiae. The predicted amino acid sequence (M(r) 471,305) reveals the presence of four P-loop motifs, as in all dyneins known so far, and has 28% overall identity to the dynein heavy chain of Dictyostelium [Koonce, M. P., Grissom, P. M. & McIntosh, J. R. (1992) J. Cell Biol. 119, ...
متن کاملOctagonal Nuclear Pores
Negative staining of isolated nuclear envelopes by phosphotungstate shows that the nuclear pores are octagonal rather than circular. Pores of the same shape and approximately the same width, 663 +/- 5 A, were demonstrated in the newt, Triturus, the frog, Rana, and the starfish, Henricia. The outer and inner diameters of the annulus associated with each pore are respectively greater and less tha...
متن کاملArtificial tethering to nuclear pores promotes partitioning of extrachromosomal DNA during yeast asymmetric cell division
SUMMARY Asymmetric cell division in unicellular organisms enables sequestration of senescence factors to specific subpopulations. Accumulation of autonomously replicating sequence (ARS) plasmids, which frequently emerge from recombination within the highly repetitive ribosomal DNA locus, is linked to limited replicative life span of Saccharomyces cerevisiae cells [1]. During budding yeast cell ...
متن کاملThe path of RNA through nuclear pores
The nuclear pore acts as a gate in the nuclear envelope that permits exchange of macromolecules between nucleus and cytoplasm (reviewed by Akey, 1995; Bastos et al., 1995; Davis, 1995; Panté and Aebi, 1996; Mattaj and Englmeier, 1998; Yang et al., 1998). It is a huge wheel-like assembly (>1 MDa) of multiple copies of >100 different proteins arranged with eightfold symmetry. A central transporte...
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ژورنال
عنوان ژورنال: Nature
سال: 2010
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature09255